Rovers are currently just five points behind sixth-placed Reading following last weekend's 2-0 win over Blackpool at Ewood Park.
Gary Bowyer's side have only been beaten once in the league in 2014 so far, winning three and drawing the remaining two of their matches this year.
However, they know that they can't afford many slip-ups with six teams realistically still looking to displace the Royals in the final playoff spot.
Blackburn have struggled for consistency for much of the season, and they will need to address that problem if they are to sneak into the top six.
A good place to start would be by improving their away form as they have only managed three wins on the road all season, although two of those victories have come in their last four outings.
Bowyer could name an unchanged side for the match, although Markus Olsson is pushing for a start having recently returned to fitness.
A win for the visitors could effectively end Middlesbrough's playoff hopes, but should the result go the other way then the hosts would be right amongst the main huddle of challengers.
Only runaway league leaders Leicester have been able to beat Boro in their last nine league matches, although they have not won or even scored in their last three.
Back-to-back goalless draws have left them nine points adrift of the top six, and manager Aitor Karanka knows that he can't afford to let that gap grow any bigger.
Boro do have some impressive home form to fall back on, with just one defeat since the opening day of the season and four consecutive clean sheets at the Riverside, including keeping out the likes of Burnley, Wigan Athletic and Reading.
Possible starting lineups
Middlesbrough: Given; Varga, Gibson, Ayala, Friend; Leadbitter, Chalobah, Carayol, Kamara, Ledesma; Graham
Blackburn: Robinson; Kane, Hanley, Kilgallon, Spurr; Taylor, Lowe, Cairney, Dunn; Gestede, Rhodes
Sports Mole says: 1-1