The Hornets are unbeaten in their last seven outings, and a win this weekend could be enough for them to reclaim top spot in the division.
Slavisa Jokanovic is likely to be without Almen Abdi for the trip after he was forced off with a shoulder injury earlier this week, while the head coach also confirmed that Troy Deeney is not yet fit enough for a place in the starting XI.
Meanwhile, the hosts will be looking for a win that would see them move above their opponents and into the automatic promotion places.
When the sides last played in February this year, both teams finished with 10 men on the pitch, but it was Watford who came away with the win.
Possible starting lineups
Middlesbrough: Konstantopoulos, Fredericks, Ayala, Omeruo, Friend, Adomah, Leadbitter, Whitehead, Tomlin, Vossen, Kike
Watford: Gomes, Paredes, Ekstrand, Bassong, Pudil, Murray, Tozser, Munari, Vydra, Forestieri, Ighalo
Sports Mole says: 1-1