Meanwhile, Brentford will be hoping to bounce back from just their second defeat of the season after they were beaten 3-0 by Norwich City earlier this week.
Despite the loss, the Bees remain in the top half of the table in 11th, just two points off the playoff places.
The team are not expected to have any new injuries for Saturday's match, but will continue to be without Scott Hogan, who is a long-term absentee with a knee injury.
This will be the first time that these two sides have played since 2003, when Middlesbrough knocked Brentford out of the League Cup with a 4-1 win.
Possible starting lineups
Middlesbrough: Konstantopoulos, Ayala, Omeruo, Nsue Lopez, Friend, Adomah, Clayton, Reach, Leadbitter, Tomlin, Martinez
Brentford: Button, Tarkowski, Bidwell, McCormack, Dean, Judge, Douglas, Dallas, Odubajo, Pritchard, Proschwitz.
Sports Mole says: 2-0