The hosts have hit a spell of bad form in recent weeks, winning just one of their last five matches in all competitions, including their only two league losses of the season so far.
Lyon, meanwhile, have lost just one of their 14 games in all competitions this season and go into the fixture on the back of a 2-1 win over Spanish side Athletic Bilbao in their midweek Europa League match.
Should league leaders Paris Saint-Germain fail to win their game, the winner of this match would go top of the table.
Marseille: Mandanda; Abdallah, Fanni, N'Koulou, Morel; Amalfitano, Kabore, Cheyrou, Ayew; Valbuena; Remy
Lyon: Vercoutre; Reveillere, Lovren, Bisevac, Dabo; Briand, Gonalons, Malbranque, Lacazette; Gomis, Lopez
Sports Mole says: 0-1