Juventus are reportedly preparing a January offer for Manchester United midfielder Paul Pogba.
The France international, who is currently on the sidelines with an ankle injury, is allegedly determined to secure a return to the Old Lady despite firm interest from Real Madrid.
Mandzukic and Can have both been left out of Maurizio Sarri's Champions League squad this season, but Matuidi remains a key player for the Italian champions in the middle of the park.
Rugani, meanwhile, has struggled for action this term but did start against Lokomotiv Moscow in the Champions League earlier this week due to Matthijs de Ligt's absence.
Pogba - thought to be valued upwards of £150m by his Premier League club - won four Serie A titles with the Old Lady before securing a return to United, where he has a contract until the end of the 2020-21 campaign.