Paul Scholes and Anderson begin in central midfield and Wayne Rooney is up front with Danny Welbeck.
Dani Alves, Carles Puyol and Javier Mascherano are all in defence for Barca, with Andres Iniesta and Lionel Messi also in the side.
Man Utd: De Gea; Valencia, Ferdinand, Vidic, Evra; Nani, Anderson, Scholes, Young; Rooney, Welbeck
Subs: Lindegaard, Berbatov, Hernandez, Carrick, Powell, Kagawa, Macheda, Wooton, Brady, Keane, Lingard
Barcelona: Valdes; Alves, Puyol, Mascherano, Adriano; Alexis, Iniesta, Busquets, Sergi Roberto, Tello; Messi