In all, Jose Mourinho makes two changes from the XI that started their goalless draw with Liverpool last weekend, as Romelu Lukaku continues to lead the line with support from Jesse Lingard, Anthony Martial and Juan Mata.
Rashford limped off during United's 1-0 win at Benfica in the Champions League in midweek but is passed fit enough to start among the substitutes this afternoon.
Aaron Mooy replaces Rajiv van La Parra alongside Tom Ince and Elias Kachunga in attacking midfield, while Danny Williams comes in for Philip Billing as partner for Jonathan Hogg in front of the back four.
Huddersfield Town: Lossl; Lowe, Schindler, Jorgensen, Smith; Hogg, Williams; Ince, Mooy, Kachunga; Depoitre
Subs: Coleman, Malone, Sabiri, Cranie, van La Parra, Mounie, Hadergjonaj
Manchester United: De Gea; Valencia, Smalling, Jones, Young; Herrera, Matic; Lingard, Mata, Martial; Lukaku
Subs: Romero, Blind, Darmian, Lindelof, McTominay, Rashford
Keep up with all of the action from Huddersfield this afternoon with Sports Mole's live text commentary here.