Eight days ago, Lingard came off the bench to score United's winning goal in the 2-1 triumph at home to Chelsea and the England international has been rewarded with a place in the side for the game in London.
Anthony Martial is the man to drop out of the team, with the attacker not involved in the 18-man squad, and it is the only alteration made by Mourinho.
New signing Diego Cavalieri features on the bench after arriving at the Eagles on a free transfer.
Crystal Palace: Hennessey; Wan-Bissaka, Kelly, Tomkins, Van Aanholt; Townsend, McArthur, Milivojevic, Schlupp; Benteke, Sorloth
Subs: Cavalieri, Souare, Delaney, Rakip, Jach, Riedewald, Lee
Manchester United: De Gea; Valencia, Lindelof, Smalling, Young; Matic, McTominay, Pogba; Lingard, Sanchez, Lukaku
Subs: Pereira, Bailly, Darmian, Shaw, Carrick, Mata, Rashford
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