The Spaniard, with four goals and three assists in the top flight this term, was an unused sub in the 3-2 win over Manchester City last weekend.
Jonny Evans misses out on a return to Old Trafford through injury, though there is some better news for Championship-bound Albion as Daniel Sturridge is back among the subs, as is young midfielder Sam Field.
West Brom have won three of the nine Premier League matches against Man United since Sir Alex Ferguson retired in 2013.
Manchester United: De Gea; Valencia, Smalling, Lindelof, Young; Matic, Herrera, Pogba; Mata, Sanchez, Lukaku
Subs: Pereira, Jones, Rojo, McTominay, Lingard, Martial, Rashford
West Bromwich Albion: Foster; Nyom, Dawson, Hegazi, Gibbs; Phillips, Livermore, Brunt, McClean; Rodriguez, Rondon
Subs: Myhill, Gabr, Yacob, Krychowiak, Field, Burke, Sturridge
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