The Belgian international will lead the Red Devils out against former boss David Moyes, whose Black Cats side are in desperate need of three points as they sit bottom of the table and are now 10 adrift of safety.
Pogba comes in for his first start since picking up an injury against Rostov on March 16, while Shaw's inclusion comes on the back of some stinging public criticism from his manager in recent weeks.
Sergio Romero also comes in for David de Gea between the sticks and Matteo Darmian deputises for Ashley Young, with Henrikh Mkhitaryan ahead of Marcus Rashford the other alteration from last time out.
Lamine Kone and Jason Denayer again form the core of Sunderland's defence as John O'Shea is absent due to the recent death of his father, as the Black Cats go in search of just a fourth win in 32 league attempts against today's opponents.
There is no place in the squad for Adnan Januzaj this afternoon, meanwhile, as he is ineligible to feature against his parent club.
Sunderland: Pickford, Oviedo, Denayer, Jones, Kone, Ndong, Larsson, Cattermole, Rodwell, Defoe, Anichebe
Subs: Mannone, Djilobodji, Borini, Khazri, Manquillo, Pienaar, Gibson
Manchester United: Romero, Darmian, Bailly, Rojo, Shaw, Fellaini, Herrera, Pogba, Mkhitaryan, Ibrahimovic, Lingard
Subs: Pereira, Blind, Fosu-Mensah, Tuanzebe, Carrick, Martial, Rashford
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