Recent history would suggest that they should claim the victory, having won on their last four visits to the East London-based outfit. What's more, the hosting Hammers have only managed to score two goals during those encounters.
Ferguson's team have also been in good form on the road all season. From 16 trips, they've only lost twice, winning on 12 occasions.
The Scotsman is expected to make a handful of changes to his starting lineup from the 2-0 win at Stoke City. Danny Welbeck, Tom Cleverley, Chris Smalling and Ryan Giggs all missed that clash and the quartet are likely to earn recalls.
When these sides met at the same venue in the FA Cup earlier this season, a stoppage-time goal from Robin van Persie earned Man United a 2-2 draw.
West Ham: LWLWDD
Man United: WWWWLW
Possible starting lineups
West Ham: Jaaskelainen; Tomkins, O'Brien, Collins, Demel; Nolan, Jarvis, Collison, Diame, Taylor; Carroll
Man United: De Gea; Jones, Smalling, Ferdinand, Evra; Nani, Giggs, Carrick, Cleverley; Welbeck, Van Persie
Sports Mole says: 2-2