The Red Devils, who are three points adrift of City in the table, have welcomed back Chris Smalling, who should slot back into defensive duty alongside Rio Ferdinand, Patrice Evra and Phil Jones.
Danny Welbeck could partner Wayne Rooney up front after scoring in the Premier League champions' 3-2 FA Cup win over Manchester City on Sunday, leaving Dimitar Berbatov and Javier Hernandez to fight for their place.
Goalkeeper Jussi Jaaskelainen remains on the sidelines with an injury, therefore Adam Bogdan should continue in goal for the Lancashire side. Former Liverpool striker David N'Gog could get the nod over Tuncay Sanli and Ivan Klasnic following his goal against Everton last week.
Manchester United: WWWWLL
Manchester United: De Gea; Ferdinand, Smalling, Evra, Jones; Carrick, Anderson, Nani, Valencia; Rooney, Welbeck
Bolton: Bogdan; Wheater, Knight, Ricketts, Steinsson; Muamba, Reo-Coker, M.Davies, Petrov; Eagles, N'Gog
Sports Mole says: 3-0