The Red Devils have now lost seven matches at Old Trafford since the start of the campaign following Saturday's 1-0 defeat to Sunderland.
However, despite a number of low points since August, Ryan Giggs's side still have a chance of qualifying for the Europa League.
A win on Tuesday would take them to within three points of sixth-placed Tottenham Hotspur going into the final weekend, and United can claim to be boosted further by having a better goal difference than Tim Sherwood's side.
Meanwhile, Hull head to the Theatre of Dreams looking to put an end to a winless run of three matches in the top flight.
The Tigers have been in indifferent form ahead of their trip to Wembley Stadium for the FA Cup final at the end of the month, with manager Steve Bruce recently admitting that his players are struggling to focus.
United have no fresh injury concerns ahead of the match, though Wayne Rooney could return following a groin complaint. Allan McGregor, Robbie Brady and Paul McShane all remain sidelined for the visitors.
Man Utd: DWLLWL
Possible starting lineups
Man Utd: De Gea; Jones, Ferdinand, Vidic, Evra; Kagawa, Carrick, Fletcher; Rooney, Mata, Van Persie
Hull: Harper; Rosenior, Figueroa, Chester, Davies; Meyler, Huddlestone, Livermore, Elmohamady; Jelavic, Long
Sports Mole says: 2-0