The Red Devils saw their hopes of clinching the title given a huge boost on Sunday as holders Manchester City were defeated 3-1 at Tottenham Hotspur.
The gap between the two sides now stands at 13 points with 15 more up for grabs before the end of the season.
Meanwhile, a surprise win for struggling Villa at the Theatre of Dreams would see both Reading and Queens Park Rangers relegated from the top flight with four games left to play.
Gabriel Agbonlahor is expected to overcome a thigh strain for the visitors, who have no fresh injury concerns ahead of the match.
Man Utd: WWLLWD
Man Utd: De Gea; Rafael, Ferdinand, Vidic, Evra; Valencia, Carrick, Giggs; Kagawa; Rooney, Van Persie
Villa: Guzan; Vlaar, Bennett, Baker, Lowton; N'Zogbia, Westwood, Delph; Agbonlahor; Benteke, Weimann
Sports Mole says: 3-1