The Red Devils suffered a 2-0 loss at Watford on Sunday afternoon and will therefore be determined to return to winning ways on Thursday.
That said, the 20-time English champions have only suffered one loss at Old Trafford in the Premier League this season, while they are unbeaten at home to Newcastle in England's top flight since December 2013.
Here, Sports Mole looks at how United could line up when they welcome Steve Bruce's side.
Solskjaer hinted during Sunday's post-match press conference that Pogba, having made his return off the bench at Watford, was likely to go into the XI for the clash with Newcastle.
The Norwegian also talked up the Frenchman's versatility, and it would not be a surprise to see him selected in the number 10 spot against Newcastle with Jesse Lingard, who missed a big chance at Vicarage Road when the score was goalless, dropping out.
James has been excellent since arriving from Swansea City, but the Wales international could be rested ahead of the trip to Turf Moor.
The team's injury list is certainly now easing, although Eric Bailly, Timothy Fosu-Mensah and Marcos Rojo will all miss out for the Red Devils once again.