The Red Devils make the trip to East London needing just seven more points to secure the Premier League title.
Having recently come up against Stoke, Serbian centre-back Vidic believes that Wednesday's visit to Upton Park will provide his team with another physical battle.
"Stoke is always a difficult place to go to but we fought for every ball, played some good football and, in the end, I think we deserved to win," he told MUTV.
"It was physical. You know they're going to get the ball to the forwards, they're good at set-pieces, they're going to challenge defenders.
"Now it's West Ham and we have to play well again. They play in a similar style to Stoke. We're going to have long balls and set-pieces to deal with."
United have won on their last four trips to West Ham.