The ex-England international urged manager Jose Mourinho to show the duo more support and encourage them to stay at Old Trafford.
"These young players need an arm around them these days, they need a bit of love at times and they aren't really getting that. Would they improve if they get that? I hope that they would," Scholes told talkSPORT.
"I know they're good players, they're really talented players.
"Those two especially, I just don't want them to be players who leave and turn out to be sensational, because you can easily see that happening."
Martial was recently linked with a move to Tottenham Hotspur.