"It is always hard to play against Stoke because they play a different kind of football to most teams in the Premier League," Nani told MUTV. "They are very physical and have very strong players.
"It is also difficult because most of the game is in the air. We need to be strong and try to play our game.
"We are playing at home and we have to believe we can win the three points. It is very important because when you play at home, you have a good chance to win these games."
United have won all four of their home fixtures against Stoke in the Premier League.