The England international has been absent for the North-West outfit's last two games with a groin injury, but returned to training this week.
"Wayne and Rafa have started training this morning which is good news," Ferguson said in a press conference. "Hopefully, they will be fine by Monday.
"Jonny Evans and Nemanja Vidic are not there yet but, hopefully, they will start training maybe tomorrow or Saturday morning. We have a little bit of time on our hands to get most of the troops ready for the game."
United are currently 15 points ahead of their rivals at the top of the Premier League table.