The Red Devils are currently sixth in the division, two points ahead of seventh-placed West Ham United, while Palace sit 13th following their 3-2 loss at Everton, and here Sports Mole rounds up the team news.
Sports Mole's predicted XI: Guaita; Clyne, Andersen, Kouyate, Mitchell; Gallagher, Milivojevic, Eze; Ayew, Mateta, Zaha
Out: Mason Greenwood (club suspension), Cristiano Ronaldo (hip)
Sports Mole's predicted XI: De Gea; Dalot, Maguire, Varane, Telles; Fred, McTominay, Matic; Elanga, Fernandes, Rashford
For additional data used by our team to analyse our suggested result please click here.