The Belgian received a red card after the final whistle of Sunday's 2-0 defeat for an off-the-ball incident with Ezri Konsa and will start his three-match suspension on Thursday.
Eagles boss Roy Hodgson will also be without centre-backs Gary Cahill (hamstring) and James Tomkins (thigh), but Jeffrey Schlupp has returned to training after a hip injury and will be on the bench for the Red Devils visit.
Forward Greenwood has a swollen ankle after a hefty challenge from Oriol Romeu during Monday's 2-2 draw with Southampton, while left-back Shaw suffered a twisted an ankle against his former club and his replacement Williams was forced off after a nasty clash of heads with Kyle Walker-Peters.
United boss Ole Gunnar Solskjaer has named an unchanged starting line-up for five successive Premier League matches and said "there might be one or two fresh legs coming in". Axel Tuanzebe and Phil Jones remain out.
Crystal Palace provisional squad: Guaita, Ward, Dann, Sakho, Van Aanholt, Milivojevic, Kouyate, McArthur, McCarthy, Ayew, Zaha, Townsend, Hennessey, Kelly, Schlupp, Woods, Tavares, Mitchell, Meyer, Pierrick, Riedewald.
Manchester United provisional squad: De Gea, Romero, Grant, Bishop, Dalot, Fosu-Mensah, Wan-Bissaka, Bailly, Lindelof, Mengi, Laird, Maguire, Shaw, Williams, Pogba, Matic, McTominay, Fred, Fernandes, Pereira, Lingard, Garner, Mata, Chong, James, Ighalo, Greenwood, Martial, Rashford.