The 31-year-old has not featured for the first team since February due to an ankle injury, but played 60 minutes of the match and came through it unscathed.
Van Persie set up Sean Goss's goal as Manchester United drew 1-1.
Jonny Evans also made his comeback following his six-match suspension for spitting at Newcastle United's Papiss Cisse.
Restore Data
| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | Manchester CityMan City | 32 | 22 | 7 | 3 | 76 | 32 | 44 | 73 |
| 2 | Arsenal | 32 | 22 | 5 | 5 | 75 | 26 | 49 | 71 |
| 3 | Liverpool | 32 | 21 | 8 | 3 | 72 | 31 | 41 | 71 |
| 4 | Aston Villa | 33 | 19 | 6 | 8 | 68 | 49 | 19 | 63 |
| 5 | Tottenham HotspurSpurs | 32 | 18 | 6 | 8 | 65 | 49 | 16 | 60 |
| 6 | Newcastle UnitedNewcastle | 32 | 15 | 5 | 12 | 69 | 52 | 17 | 50 |
| 7 | Manchester UnitedMan Utd | 32 | 15 | 5 | 12 | 47 | 48 | -1 | 50 |
| 8 | West Ham UnitedWest Ham | 33 | 13 | 9 | 11 | 52 | 58 | -6 | 48 |
| 9 | Chelsea | 31 | 13 | 8 | 10 | 61 | 52 | 9 | 47 |
| 10 | Brighton & Hove AlbionBrighton | 32 | 11 | 11 | 10 | 52 | 50 | 2 | 44 |
| 11 | Wolverhampton WanderersWolves | 32 | 12 | 7 | 13 | 46 | 51 | -5 | 43 |
| 12 | Fulham | 33 | 12 | 6 | 15 | 49 | 51 | -2 | 42 |
| 13 | Bournemouth | 32 | 11 | 9 | 12 | 47 | 57 | -10 | 42 |
| 14 | Crystal Palace | 32 | 8 | 9 | 15 | 37 | 54 | -17 | 33 |
| 15 | Brentford | 33 | 8 | 8 | 17 | 47 | 58 | -11 | 32 |
| 16 | Everton | 32 | 9 | 8 | 15 | 32 | 48 | -16 | 27 |
| 17 | Nottingham ForestNott'm Forest | 33 | 7 | 9 | 17 | 42 | 58 | -16 | 26 |
| 18 | Luton TownLuton | 33 | 6 | 7 | 20 | 46 | 70 | -24 | 25 |
| 19 | Burnley | 33 | 4 | 8 | 21 | 33 | 68 | -35 | 20 |
| 20 | Sheffield UnitedSheff Utd | 32 | 3 | 7 | 22 | 30 | 84 | -54 | 16 |
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