The Red Devils have beaten Luton Town and Brighton & Hove Albion in the EFL Cup since losing to Crystal Palace in their opening match of the new Premier League season.
The 20-time English champions now face a tough assignment against Jose Mourinho's side at Old Trafford.
Here, Sports Mole rounds up the team's injury and suspension news ahead of the contest.
Type of injury: Foot
Possible return date: October 17 (vs. Newcastle United)
Axel Tuanzebe is now back training on the grass following a long-term foot injury, but the versatile defender will not be considered for this weekend's clash with Tottenham.
Type of injury: Knee
Possible return date: Unknown
Phil Jones has not featured for United since January due to a long-term knee problem, and the Englishman will also not be involved on Sunday afternoon.
MANCHESTER UNITED'S SUSPENSION LIST
United have no players suspended for the Premier League clash.