The Red Devils are unbeaten in six matches in all competitions, including a 1-1 draw against Brugge in the first leg of their last-32 tie last week.
Here, Sports Mole looks at how Ole Gunnar Solskjaer may set out his side.
Paul Pogba is still not ready for a return to the squad and Marcus Rashford is in a battle to be fit again before the end of the campaign.
McTominay was a key figure for United before picking up an untimely injury and could return to the starting XI here, with Andreas Pereira a contender to join him in defensive midfield.
Odion Ighalo has made three substitute appearances since arriving on loan in January and his wait for a full debut is expected to go on, with Martial ready to go again.
Elsewhere, Jesse Lingard will be hoping for a recall to the squad after being overlooked entirely at the weekend, while Brandon Williams, Sergio Romero, Eric Bailly and Juan Mata are also back in contention.