The Ukrainian giants maintained their perfect record in Europe thanks to a 5-0 thrashing of Gent at the Arena Lviv, courtesy of strikes from Viktor Kovalenko, Facundo Ferreyra, Bernard, Taison and Maksym Malyshev.
Paulo Fonseca's charges continue to top Group H and have opened up a five-point gap between themselves and Gent, while Braga and Konyaspor, who played out a 1-1 draw on Thursday, have two points and one point respectively.
Schalke also continue to boast a 100% record in the Europa League thanks to their narrow 1-0 win at FC Krasnodar.
Evgen Konoplyanka's 11th-minute strike from the edge of the box settled an even Group I match at the Krasnodar Stadium between two sides that had both won their two opening games.
Results in full:
Celta Vigo 2-2 Ajax, Steaua Bucuresti 1-1 FC Zurich, Hapoel Be'er Sheva 0-1 Sparta Prague, Inter Milan 1-0 Southampton, Konyaspor 1-1 Braga, Krasnodar 0-1 Schalke, Slovan Liberec 1-3 Fiorentina, Osmanlispor 2-2 Villarreal, Qarabag FK 2-0 PAOK, Salzburg 0-1 Nice, Shakhtar Donetsk 5-0 Gent, Standard Liege 2-2 Panathinaikos, Roma 3-3 Austria Vienna, AZ 1-2 Maccabi Tel Aviv, Dundalk 1-2 Zenit St Petersburg, Feyenoord 1-0 Zorya Luhansk, Genk 2-0 Athletic Bilbao, Mainz 05 1-1 Anderlecht, Manchester United 4-1 Fenerbahce, Olympiacos 4-1 FC Astana, Plzen 1-2 Astra, Rapid Vienna 1-1 Sassuolo, St Etienne 1-0 Gabala, Young Boys 3-1 APOEL