The 30-year-old defender has been rested for the clash, while Nemanja Vidic has recovered from a calf injury to return to the lineup. Forward Dimitar Berbatov is also back, while Phil Jones has overcome his knock at Anfield on Saturday to be included.
Alex Ferguson and his team departed the UK for Romania this morning.
The squad: De Gea, Lindegaard, Amos, Evans, Evra, Fabio, Jones, Smalling, Vidic, Anderson, Carrick, Fletcher, Giggs, Nani, Park, Young, Valencia, Berbatov, Diouf, Hernandez, Owen, Rooney, Welbeck.
Earlier, Ferguson set his players the target of winning both legs against Galati.