The Reds held on for a 1-0 win over Napoli which sealed their place in the last 16, while Spurs needed a late equaliser against Barcelona - and a slip-up by Inter Milan at home to PSV Eindhoven - to make it a clean sweep of English clubs in the knockout rounds.
Manchester City secured top spot in their group by beating Hoffenheim, but Manchester United could not do the same as they slumped to defeat at the hands of Valencia when victory would have been enough to leapfrog Juventus, who were stunned by Young Boys.
Here, Sports Mole selects its Champions League team of the week for matchday six.
One of the most oft-repeated Champions League statistics of recent years have been regarding Igor Akinfeev's 11-year wait for a clean sheet, stretching from 2006 to 2017, but he now has one at the Bernabeu to celebrate. The veteran made six saves during his side's remarkable win over Madrid, beating competition from Alisson Becker and Jeroen Zoet for the gloves.
Akinfeev is joined in this XI by teammate Hordur Magnusson, who won a game-high six aerial battles to help keep the champions at bay. Alongside him is Paris Saint-Germain's Marquinhos, who scored during his side's win over Red Star Belgrade - albeit from a more advanced position than he plays in this side.
The same is true of Borussia Dortmund's Raphael Guerreiro, who scored both of his side's goals during their 2-0 win at Monaco. Guerreiro's goals came from an attacking left position, but he is a more regular left-back and the quality of the performances by those further up the field means that he deserves a place in the team - even at the expense of Benfica's Alejandro Grimaldo.
Liverpool's battling performance over Napoli earns them two representatives in this side, with Trent Alexander-Arnold earning his place at right-back while James Milner is in midfield, having supplied the assist for Mohamed Salah's all-important goal.
There were not too many outstanding midfield performances around Europe this week, but Ilkay Gundogan delivered a solid enough display to join his Premier League rival in the holding midfield role - one of two players selected from Manchester City's win over Hoffenheim.
Leroy Sane was the star of that particular show with both of his side's goals as they came from behind, and the German winger holds off some stiff competition in the fiercely-contested forward positions as the likes of Nikola Vlasic, Nabil Fekir and Arnor Sigurdsson all miss out.
It is a PSG pairing which completes the trio behind the striker, with Neymar having scored one and created another in Belgrade only to see Kylian Mbappe go one better with two assists to add to his goal as the Ligue 1 champions topped Group C.
Arguably the most entertaining game of the round came in Amsterdam where Ajax and Bayern Munich played our a 3-3 draw which saw Robert Lewandowski add two more goals to his competition-leading tally, narrowly beating competition from the Young Boys hero Guillaume Hoarau, who got both of his side's goals against Juventus.