The Citizens are closing in on a fifth title in 10 seasons, while opponents Leicester can move into second place - even if only temporarily - with a victory this weekend.
Here, Sports Mole rounds up all of the latest team news for the two clubs.
Sports Mole's predicted XI: Schmeichel; Soyuncu, Evans, Fofana; Albrighton, Tielemans, Ndidi, Praet, Castagne; Vardy, Iheanacho
Sports Mole's predicted XI: Ederson; Walker, Stones, Dias, Cancelo; De Bruyne, Rodrigo, Gundogan; Mahrez, Jesus, Sterling
Watch the Sports Mole Football Shorts prediction for this game below: