Stones, who has been sidelined with an adductor problem in recent weeks, has not featured for City since early March, but is thrown straight back into the starting lineup by manager Pep Guardiola this afternoon.
City go into the game knowing that a victory and two goals will see them set new Premier League records for the number of points, wins and goals in a single campaign.
Relegation-threatened Huddersfield have also made two changes to their starting lineup for the match, with captain Tommy Smith and Chris Lowe both returning to the side - the latter of whom makes his first Premier League start since January.
Smith faces the club where he spent eight years as a youth player, while midfielder Aaron Mooy will also come up against his former employers this afternoon.
Manchester City: Ederson; Walker, Stones, Otamendi, Delph; Fernandinho, De Bruyne, Sane, Silva, Sterling; Jesus
Subs: Bravo, Gundogan, Laporte, Bernardo, Mendy, Yaya Toure, Foden
Huddersfield Town: Lossl; Smith, Zanka, Schindler, Lowe; Hogg, Mooy, Kongolo, Hadergjonaj, Pritchard; Mounie
Subs: Coleman, Malone, Billing, Van La Parra, Depoitre, Quaner, Stankovic
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