The youngster comes in for Kevin De Bruyne, who has been ruled out for up to 10 weeks after being injured in the 2-2 draw at West Ham United 10 days ago, playing alongside Jesus Navas and David Silva as support for lone forward Sergio Aguero.
The visiting Black Cats waste no time bringing their mid-season signings into the fold, with Lamine Kone and Jan Kirchhoff starting at the centre of a five-man backline as Wes Brown and Adam Johnson drop to the bench.
Sunderland: Mannone; Jones, O'Shea, Kone, Kirchhoff, Van Aanholt; Cattermole, M'Vila, Borini, Lens; Defoe
Subs: Pickford, Brown, N'Doye, Johnson, Khazri, Yedlin, Watmore
Manchester City: Hart; Sagna, Demichelis, Otamendi, Clichy; Fernandinho, Yaya Toure; Navas, Silva, Iheanacho; Aguero
Subs: Caballero, Kolarov, Zabaleta, Fernando, Celina, Barker, Sterling
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