While the midfielder is not expected to feature on Sunday, familiar faces should fill the City side, including captain Vincent Kompany, who will line the back four with Sergio Aguero and Carlos Tevez partnering up front.
Meanwhile, Southampton boss Nigel Adkins is expected to be without Jack Cork after the midfielder picked up an ankle problem during the Saints' pre-season schedule. However, new signings Nathaniel Clyne and Jay Rodriguez are in contention to start at the Etihad Stadium this weekend.
Manchester City: Hart; Zabaleta, Kompany, Lescott, Clichy; Yaya Toure, De Jong; Silva, Nasri; Tevez, Aguero
Southampton: K Davis; Clyne, Fonte, Hooiveld, Fox; Guly, Schneiderlin, S Davis, Lallana; Rodriguez, Lambert
Sports Mole says: 3-0