City sit six points adrift of leaders Liverpool with a game in hand, and anything other than victory at Selhurst Park will damage the club's hopes of a second Premier League crown in three years.
Crystal Palace boss Tony Pulis has guided the Eagles to five successive wins in the Premier League to guarantee their top-flight status for another year.
Last weekend's 1-0 win at West Ham United strengthened Palace's hold on 11th position, and a sixth victory in a row could see the London outfit move into the top half of the table.
Pulis is unlikely to make any alterations to the team that won at Upton Park.
Crystal Palace: LWWWWW
Manchester City: WDWLDW
Possible starting lineups
Crystal Palace: Speroni; Mariappa, Ward, Dann, Delaney; Dikgacoi, Puncheon, Jedinak, Ledley, Bolasie; Jerome
Manchester City: Hart; Zabaleta, Clichy, Kompany, Demichelis; Fernandinho, Nasri, Javi García, Milner, Jovetic; Aguero
Sports Mole says: 1-3