However, they will be firm favourites to return to winning ways at the first time of asking this weekend, despite Fulham's victory at Leicester City last time out.
Here, Sports Mole looks at how Pep Guardiola could set his side up for the contest.
Doubtful: Sergio Aguero (knee)
Guardiola almost has a clean bill of health for this match, although the one doubt is a significant one with Sergio Aguero still yet to get a run of games during an injury-plagued season so far.
The Argentine has missed the last two matches with a knee problem and, while Guardiola has insisted that it is nothing serious, he remains a major doubt for this one.
Gabriel Jesus is therefore expected to lead the line after being rested in midweek, while Kevin De Bruyne, Benjamin Mendy, Kyle Walker and Ilkay Gundogan are among the other players set to return to the starting XI.
Riyad Mahrez should return to the side too, having scored a hat-trick against Burnley to leap to the top of Man City's top-scorers list this season.
Raheem Sterling was left out against the Clarets and, after playing the full 90 minutes in midweek, may face a similar fate this weekend with Ferran Torres set to start ahead of both him and Phil Foden.
Watch the Sports Mole Football Shorts prediction for this game below: