The Blues started their campaign in emphatic fashion last month with a 7-0 thrashing of Championship side Sheffield Wednesday.
Meanwhile, Newcastle travel to the Etihad Stadium with the wind in their sails after beating Tottenham Hotspur 2-1 at White Hart Lane at the weekend.
Following their poor start to the season, the Magpies are now up to 14th place in the standings thanks to two victories in their last two matches.
Alan Pardew's side booked their place in round four of the League Cup last month with a dramatic 3-2 triumph away to Crystal Palace.
Manchester City will be without Samir Nasri and Frank Lampard, while Willy Caballero, Aleksandar Kolarov, Martin Demichelis and Fernandinho could all be called upon if manager Manuel Pellegrini shakes up his team ahead of this weekend's derby with Manchester United.
Man City: WDWWDL
Possible starting lineups
Man City: Caballero; Kolarov, Demichelis, Kompany, Sagna; Milner, Fernandinho, Fernando, Navas; Jovetic, Dzeko
Newcastle: Krul; Janmaat, Coloccini, Williamson, Dummett; Colback, Anita; Cabella, Sissoko, Gouffran; Ameobi
Sports Mole says: 2-0