The winners of the competition in each of the last four seasons will travel to London Stadium without Ferran Torres, who will not feature again this year after sustaining a metatarsal injury.
Man City could also be without Raheem Sterling, who missed Saturday's 4-1 win at Brighton & Hove Albion due to lower back pain and remains a doubt.
Zack Steffen should replace Ederson in goal, while there could be rare outings for defensive trio John Stones, Nathan Ake and Oleksandr Zinchenko, despite Guardiola naming an inexperienced and unfamiliar back four of Egan-Riley, Finley Burns, Luke Mbete-Tabu and Josh Wilson-Esbrand in the last round.
Liam Delap will play no part as he continues to struggle with an ankle injury, and the academy's biggest recent success story Phil Foden is expected to be rested too, despite registering three goals and six assists in his last seven EFL Cup starts.
Manchester City possible starting lineup: Steffen; Egan-Riley, Stones, Ake, Zinchenko; De Bruyne, Fernandinho, Palmer; Mahrez, Jesus, Grealish