With six matches remaining, Pep Guardiola's side require a maximum of 11 points to claim their third top-flight crown in four seasons.
However, City head into this contest on the back of a 1-0 defeat to Chelsea in the FA Cup semi-finals, a result which ended their hopes of winning the quadruple.
Here, Sports Mole rounds up all of City's latest injury and suspension news ahead of the fixture in the West Midlands.
Status: Major doubt
Type of injury: Muscular
Possible return date: April 21 (vs. Villa)
While Aguero enjoyed a run of appearances before the international break, the Argentine has not been seen since lasting 63 minutes against Leicester City on April 3. Guardiola has cited a 'number of niggles' as the reason for the forward's absence, which could be prolonged until at least the weekend.
Type of injury: Ankle
Possible return date: Unknown
De Bruyne sustained an ankle injury during the early stages of the second half against Chelsea, an issue which led to his immediate withdrawal. After the game, Guardiola suggested that the playmaker faced some time on the sidelines, effectively ruling the Belgian out of this contest.
MAN CITY'S SUSPENSION LIST
City have no suspension concerns for this game.