The former champions have lost each of their last three league games on the road - the first time that has happened in Pep Guardiola's managerial career - while stretching even further back five of their last eight such outings have ended in defeat.
Here, Sports Mole rounds up City's latest injury and suspension news ahead of Saturday's trip to the South Coast.
Type of injury: Knee
Possible return date: Unknown
Man City's solitary injury concern is Sergio Aguero, who has been ruled out for the remainder of the Premier League season after undergoing knee surgery. The club-record goalscorer could be back for the Champions League in August, though.
MAN CITY'S SUSPENSION LIST
Man City have no players suspended for this match.