The FA Cup is the only major domestic honour missing from Pep Guardiola's resume at City, and their attention must now turn to competitions aside from the league with an EFL Cup semi-final following Sunday's match too.
Here, Sports Mole looks at how City could line up for the first of that cup double-header.
The intensity of the match against Liverpool on Thursday means that Guardiola is likely to make wholesale changes, and it would be something of a surprise if any of the starters that night are named in the XI again on Sunday.
City are still able to name a strong team, though, and a notable inclusion could be Kevin De Bruyne as he looks to get some much-needed minutes under his belt having been left on the bench against Liverpool.
The cup competitions are an ideal chance to hand first-team football to youngsters such as Phil Foden, Eric Garcia and Brahim Diaz, the latter of whom could make his farewell appearance for City having been heavily linked with Real Madrid.
Even in a second-string side Guardiola can call upon the likes of Gabriel Jesus, Riyad Mahrez, Ilkay Gundogan, Nicolas Otamendi and Kyle Walker, while Arijanet Muric will be hopeful of another chance in goal.