City have already qualified for the last 16 of the competition but will be determined to beat Plzen so that they have a shot of toppling Bayern Munich on the final matchday to top the group.
In the reverse fixture between the pair, City won 3-0 in the Czech Republic.
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City: Hart; Richards, Lescott, Demichelis, Kolarov; Milner, Javi Garcia, Fernandinho, Nasri; Dzeko, Aguero
Plzen: Kozacik; Rajtoral, Prochazka, Cisovsky, Limbersky; Horava, Horvath; Petrzela, Kolar, Duris; Tecl