The 22-year-old missed Saturday's Ligue 1 win over Lens due to a calf problem, but Pochettino has affirmed that the issue is not serious and he should be fit to lead the line at the Etihad.
Mbappe failed to register a single shot in the 2-1 first-leg defeat but will replace Mauro Icardi if fit here, while Marco Verratti and Angel Di Maria should both come back in as Pablo Sarabia and Julian Draxler drop out.
Neymar bagged his side's opener against Lens and will be up to his usual tricks on the left-hand side this week, but PSG will have to cope without the suspended Idrissa Gueye, who was sent off for a nasty tackle on Ilkay Gundogan in the first leg.
Colin Dagba came off injured after 19 minutes against Lens but was always expected to drop out for Alessandro Florenzi, and Mitchel Bakker was a surprise starter at left-back over Abdou Diallo in the first leg, but he will hope to keep his place on Tuesday.
Marquinhos followed up his goal against City with his side's second against Lens, and the Brazilian will once again partner up with Presnel Kimpembe, who along with Paredes allowed Riyad Mahrez's decisive free kick to creep through the wall last week.
PSG possible starting lineup:
Navas; Florenzi, Marquinhos, Kimpembe, Bakker; Paredes, Herrera; Di Maria, Verratti, Neymar; Mbappe