The injury-plagued Argentine, who will soon be on the lookout for a new club, played no part in the weekend's defeat to Leeds United due to a knock, and his participation at the Westfalenstadion is up in the air.
However, Guardiola could once again opt to line up without a recognised number nine - especially as Gabriel Jesus played the full 90 at the weekend - meaning another start further forward for Bernardo Silva.
Ferran Torres and Raheem Sterling started out wide against the Whites but are sure to drop out here for Riyad Mahrez and Phil Foden, with the English starlet scoring a decisive late winner in last week's first leg.
A complete overhaul in midfield should see Rodri, Ilkay Gundogan and Kevin De Bruyne - who recently penned a new deal until 2025 - take the places of Fernandinho, Oleksandr Zinchenko and Silva, assuming the latter starts as a false nine.
Man City possible starting lineup:
Ederson; Walker, Dias, Stones, Cancelo; Rodri, Gundogan, De Bruyne; Mahrez, Silva, Foden