The Citizens must now avoid defeat to the Bundesliga side to hold off Lyon for top spot in Group F, setting up a favourable two-legged tie in the first knockout round.
Home boss Pep Guardiola may be tempted to make changes on the back of Saturday's 2-0 loss to Chelsea, but there is still some work to be done when Hoffenheim arrive in midweek.
Here, Sports Mole looks at how City could line up for their final group match.
Guardiola may consider recalling Gabriel Jesus to his starting lineup after going without a recognised striker in the defeat to Chelsea.
Aguero remains absent with a groin problem, so Jesus - who bagged a hat-trick against Shakhtar Donetsk in his most recent European outing - is primed to start.
Elsewhere, Guardiola may see this as a good opportunity to give academy product Phil Foden a first start of the season in the Premier League or Champions League, while at the same time retaining some midfield experience alongside the youngster as City attempt to get the job done with minimal fuss.