The Group D rivals face off against each other in what could be a crucial match in Sao Paulo on June 19.
While admitting that England have "very good players" in their squad, Suarez believes that Uruguay have the talent to get a positive result against the Three Lions.
"I think they have very good players that are in form and that are part of the big teams," the Liverpool forward told Perform.
"Most of the players come from the big names of the Premier League and that means a lot, but we also know that they have some troubles and we know we can hurt them."
England and Uruguay have been pitted in Group D alongside Italy and Costa Rica.