The youngster has made just one EFL Cup appearance for the senior side so far but is thrown in from the start for his top-flight debut against a Liverpool side that has dropped only two points all season.
Liverpool, meanwhile, welcome all of their big names back into the starting lineup after making 10 changes for their FA Cup triumph over Everton last time out.
Newly-crowned African Player of the Year Sadio Mane starts alongside Mohamed Salah and Roberto Firmino in the front three, while Virgil van Dijk, Trent Alexander-Arnold and Jordan Henderson are among the other first-teamers to return.
Tottenham Hotspur: Gazzaniga; Sanchez, Alderweireld, Tanganga; Aurier, Alli, Winks, Eriksen, Rose; Son, Lucas
Subs: Vorm, Vertonghen, Sessegnon, Dier, Skipp, Lamela, Lo Celso
Liverpool: Alisson; Alexander-Arnold, Gomez, Van Dijk, Robertson; Oxlade-Chamberlain, Henderson, Wijnaldum; Salah, Firmino, Mane
Subs: Adrian, Minamino, Lallana, Shaqiri, Origi, Phillips, Williams