Matip was forced off at half-time of Sunday's Premier League draw with Fulham with a back spasm and is receiving treatment, while Keita missed the match with a knock which could keep him out again.
Tottenham are likely to be without Gareth Bale for the trip to Anfield.
The Wales international is struggling with an illness that kept him out of Sunday's 1-1 draw at Crystal Palace.
Liverpool provisional squad: Alisson, Alexander-Arnold, Fabinho, Phillips, Robertson, Henderson, Wijnaldum, Jones, Salah, Firmino, Mane, Kelleher, N Williams, R Williams, Matip, Oxlade-Chamberlain, Keita, Cain, Minamino, Origi.
Tottenham provisional squad: Lloris, Hart, Gazzaniga, Doherty, Aurier, Alderweireld, Dier, Sanchez, Rodon, Davies, Reguilon, Winks, Hojbjerg, Sissoko, Fernandes, Ndombele, Lo Celso, Alli, Bergwijn, Bale, Moura, Son, Kane, Vinicius.