Borini's inclusion in the Reds' starting XI casts further doubts over the long-term future of Andy Carroll, who is among the substitutes.
Meanwhile, Romelu Lukaku, who joined the Baggies on a season-long loan from Chelsea earlier this month, starts on the bench for the hosts.
West Brom: Foster; Reid, McAuley, Olsson, Ridgewell; Mulumbu, Yacob; Morrison; Gera, Long, Odemwingie. Subs: Myhill; Jara-Reyes, Dawson, Lukaku, El Ghanassy, Brunt, Fortune
Liverpool: Reina, Johnson, Kelly, Agger, Skrtel, Lucas, Allen, Gerrard, Downing, Borini, Suarez. Subs: Jones; Adam, Henderson, Shelvey, Carroll, Carragher, Cole