The Reds can move seven points clear of City, who would still have two games in hand, but defeat against Manuel Pellegrini's team would leave Liverpool facing a tough task to win their first league title since 1990.
City go into the contest on Merseyside with their destiny in their own hands, despite sitting in third position in the standings.
Aguero has been absent for the past five matches with a hamstring problem, and Pellegrini must decide on whether to hand the Argentine an immediate start on his return to the first-team squad.
Manchester City: LWWWDW
Possible starting lineups
Liverpool: Mignolet; Johnson, Flanagan, Skrtel, Agger; Gerrard, Lucas, Henderson; Sterling, Sturridge, Suarez
Manchester City: Hart; Zabaleta, Kolarov, Kompany, Demichelis; Fernandinho, Jesus Navas, Yaya Toure, Silva, Nasri; Dzeko
Sports Mole says: 2-1