The Reds can strengthen their grip on fourth place in the Premier League to four points with a win against the Baggies.
"Obviously the derby special and everyone is up for the game, but we know what we are fighting for this season," Skrtel told the club's official website.
"We are in the top four, so we know we have a lot to play for. Now we have to be ready for the game against West Brom.
"We know it's not going to be an easy game but if we can continue with the way we played against Everton and show that form, we can get something."
The Reds beat West Brom 4-1 at Anfield earlier in the season.