The Liverpool duo are spearheading their side's title challenge, with Suarez leading the race for the Golden Boot with 29 goals, while his strike partner sits second with 20.
Reid is set to be entrusted with the task of combating the pair for the Reds' trip to Upton Park this afternoon, and the centre-back admits that he will be facing the Premier League's standout performers.
"I think it'll be one of those two," he told reporters. "Suarez has had a fantastic season. He missed the first five or six games as well so it's amazing what he's done and I'm sure his name will be right up there.
"And Daniel Sturridge has had an amazing season as well. They're good at what they do, they've got good movement, I think they link up well and they're dangerous in the box."