The Merseyside outfit take on Zenit St Petersburg on home turf with a 2-0 deficit following their loss in Russia last week, meaning that the Premier League club need to score three goals and concede none in order to get through the round-of-32 phase.
Following a recent run of negative results, the Reds head into Thursday's match on the back of a 5-0 thrashing of Swansea City in the league, while their Russian opponents have not lost a game in their last five fixtures.
Liverpool manager Brendan Rodgers will be without cup-tied duo Daniel Sturridge and Philippe Coutinho, who both scored over the weekend, which indicates that Luis Suarez will be launched up front on his own, with support from Stewart Downing and Raheem Sterling.
Meanwhile, Zenit are likely to field a strong lineup in order to keep their lead over Liverpool, who are expected to come out firing at Anfield, with Nicolas Lombaerts and Neto holding the back four, while Hulk is expected to start up top.
Zenit St Petersburg: WDWWD
Possible starting lineups
Liverpool: Reina; Johnson, Agger, Skrtel, Enrique; Henderson, Lucas, Gerrard; Downing, Sterling, Suarez
Zenit St. Petersburg: Malafeev; Anyukov, Lombaerts, Neto, Hubocan; Witsel, Danny, Denisov, Shirokov; Kerzhakov, Hulk
Sports Mole says: 1-0 (Zenit to win 2-1 on aggregate)